作者
Amanda M Fiorenza, Tatiana A Shnitko, Kaitlin M Sullivan, Sudheer R Vemuru, Alexander Gomez‐A, Julie Y Esaki, Charlotte A Boettiger, Claudio Da Cunha, Donita L Robinson
发表日期
2018/6
期刊
Alcoholism: Clinical and Experimental Research
卷号
42
期号
6
页码范围
1051-1061
简介
Background
Conditioned stimuli (CS) that predict reward delivery acquire the ability to induce phasic dopamine release in the nucleus accumbens (NAc). This dopamine release may facilitate conditioned approach behavior, which often manifests as approach to the site of reward delivery (called “goal‐tracking”) or to the CS itself (called “sign‐tracking”). Previous research has linked sign‐tracking in particular to impulsivity and drug self‐administration, and addictive drugs may promote the expression of sign‐tracking. Ethanol (EtOH) acutely promotes phasic release of dopamine in the accumbens, but it is unknown whether an alcoholic reward alters dopamine release to a CS. We hypothesized that Pavlovian conditioning with an alcoholic reward would increase dopamine release triggered by the CS and subsequent sign‐tracking behavior. Moreover, we predicted that chronic intermittent EtOH (CIE) exposure would …
引用总数
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