作者
Sarah A Schoenrock, Padam Kumar, Alexander Gómez-A, Price E Dickson, Sam-Moon Kim, Lauren Bailey, Sofia Neira, Kyle D Riker, Joseph Farrington, Christiann H Gaines, Saad Khan, Troy D Wilcox, Tyler A Roy, Michael R Leonardo, Ashley A Olson, Leona H Gagnon, Vivek M Philip, William Valdar, Fernando Pardo-Manuel de Villena, James D Jentsch, Ryan W Logan, Colleen A McClung, Donita L Robinson, Elissa J Chesler, Lisa M Tarantino
发表日期
2020/4
期刊
Psychopharmacology
卷号
237
页码范围
979-996
出版商
Springer Berlin Heidelberg
简介
Rationale
Few effective treatments exist for cocaine use disorders due to gaps in knowledge about its complex etiology. Genetically defined animal models provide a useful tool for advancing our understanding of the biological and genetic underpinnings of addiction-related behavior and evaluating potential treatments. However, many attempts at developing mouse models of behavioral disorders were based on overly simplified single gene perturbations, often leading to inconsistent and misleading results in pre-clinical pharmacology studies. A genetically complex mouse model may better reflect disease-related behaviors.
Objectives
Screening defined, yet genetically complex, intercrosses of the Collaborative Cross (CC) mice revealed two lines, RIX04/17 and RIX41/51, with extreme high and low behavioral responses to cocaine. We characterized …
学术搜索中的文章
SA Schoenrock, P Kumar, A Gómez-A, PE Dickson… - Psychopharmacology, 2020