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The present paper addresses femur failure mechanics, by numerically investigating the influence of brittle/ quasi-brittle bone constitutive description when combined with several failure criteria and different descriptions of bone ultimate parameters. Starting from computed tomography images of an experimentally-tested cadaveric femur, the bone geometry has been reconstructed through a semi-automatic segmentation procedure, and patient-specific material properties have been derived. Loading-induced loss of structural integrity has been simulated through a progressive thermodynamically-based damage model, by introducing different strain- and stress-based damage evolution laws. An in-house displacement-driven incremental approach has been implemented in a finite element framework to mimic the in-vitro experimental procedure. An energy-based regularization technique allowed to obtain results which …