作者
Lauren BA Woodruff, Ryan T Gill
发表日期
2011/8/1
来源
Current opinion in biotechnology
卷号
22
期号
4
页码范围
576-583
出版商
Elsevier Current Trends
简介
Efficiently engineering robust complex traits is a key challenge facing metabolic engineering efforts to synthesize valuable products in vivo. Recent advances in genome engineering confront this barrier and significantly enhance the ability to map functional changes targeted throughout the genome and combinatorially optimize complex (multigenic) traits using multiplex recombineering. We describe a framework for efficiently searching genome-wide combinatorial space to optimize complex traits and highlight recent advances in genome engineering that enable this approach.
学术搜索中的文章
LBA Woodruff, RT Gill - Current opinion in biotechnology, 2011