作者
Benoit G Bruneau, Zheng-Zheng Bao, Diane Fatkin, Jose Xavier-Neto, Dimitrios Georgakopoulos, Colin T Maguire, Charles I Berul, David A Kass, Mercedes L Kuroski-de Bold, Adolfo J de Bold, David A Conner, Nadia Rosenthal, Constance L Cepko, Christine E Seidman, JG Seidman
发表日期
2001/3/1
期刊
Molecular and cellular biology
卷号
21
期号
5
页码范围
1730-1736
出版商
Taylor & Francis
简介
To define the role of Irx4, a member of the Iroquoisfamily of homeobox transcription factors in mammalian heart development and function, we disrupted the murine Irx4 gene. Cardiac morphology in Irx4-deficient mice (designatedIrx4Δex2/Δex2) was normal during embryogenesis and in early postnatal life. AdultIrx4Δex2/Δex2 mice developed a cardiomyopathy characterized by cardiac hypertrophy and impaired contractile function. Prior to the development of cardiomyopathy, Irx4Δex2/Δex2 hearts had abnormal ventricular gene expression: Irx4-deficient embryos exhibited reduced ventricular expression of the basic helix-loop-helix transcription factor eHand (Hand1), increasedIrx2 expression, and ventricular induction of an atrial chamber-specific transgene. In neonatal hearts, ventricular expression of atrial natriuretic factor and α-skeletal actin was markedly increased. Several weeks subsequent to these changes …
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BG Bruneau, ZZ Bao, D Fatkin, J Xavier-Neto… - Molecular and cellular biology, 2001