作者
Vitaly Margulis, Shahrokh F Shariat, Surena F Matin, Ashish M Kamat, Richard Zigeuner, Eiji Kikuchi, Yair Lotan, Alon Weizer, Jay D Raman, Christopher G Wood, Upper Tract Urothelial Carcinoma Collaboration
发表日期
2009/3/15
期刊
Cancer
卷号
115
期号
6
页码范围
1224-1233
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
The literature on upper tract urothelial carcinoma (UTUC) has been limited to small, single center studies. A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated with poor prognosis were identified.
METHODS
Data on 1363 patients treated with radical nephroureterectomy at 12 academic centers were collected. All pathologic slides were re‐reviewed by genitourinary pathologists according to strict criteria.
RESULTS
Pathologic review revealed renal pelvis location (64%), necrosis (21.6%), lymphovascular invasion (LVI) (24.8%), concomitant carcinoma in situ (28.7%), and high‐grade disease (63.7%). A total of 590 patients (43.3%) underwent concurrent, lymphadenectomy and 135 (9.9%) were lymph node (LN) ‐positive. Over a mean follow‐up of 51 months, 379 (28%) patients experienced disease recurrence outside of the bladder …
引用总数
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