查看文章

Hexavalent chromium [Cr (VI)] is a lung carcinogen and its complete mechanism of action remains to be investigated. Metabolic reprogramming of key energy metabolism pathways (eg, increased anaerobic glycolysis in the presence of oxygen or" Warburg effect", dysregulated mitochondrial function, and lipogenesis) are important to cancer cell and tumor survival and growth. In our current understanding of Cr (VI)-induced carcinogenesis, the role for metabolic reprogramming remains unclear. In this study, we treated human lung epithelial cells (BEAS-2B) with Cr (VI) for 6 months and obtained malignantly transformed cells from an isolated colony grown in soft agar. We also used Cr (VI)-transformed cells from two other human lung cell lines (BEP2D and WTHBF-6 cells). Overall, we found that all the Cr (VI)-transformed cells had no changes in their mitochondrial respiratory functions (measured by the Seahorse …