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Objective:

To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma.

Design:

Prospective, randomized, controlled trial.

Setting:

Animal laboratory of a university hospital.

Subjects:

Thirty-five Sprague Dawley male rats (weight 257±45 g).

Interventions:

Mechanical ventilation in either supine or prone position and computed tomography scan analysis.

Measurements:

Animals were ventilated in supine (n= 15) or prone (n= 15) position until a similar ventilator-induced lung injury was reached. To do so, experiments were interrupted when respiratory system elastance was 150% of baseline. Ventilator-induced lung injury was assessed as lung wet-to-dry ratio and histology. Time to reach lung injury was considered as a main outcome measure. In five additional animals, computed tomography scans …