作者
Juan Pablo Arab, Luis Antonio Díaz, Natalia Baeza, Francisco Idalsoaga, Eduardo Fuentes-López, Jorge Arnold, Carolina A Ramírez, Dalia Morales-Arraez, Meritxell Ventura-Cots, Edilmar Alvarado-Tapias, Wei Zhang, Virginia Clark, Douglas Simonetto, Joseph C Ahn, Seth Buryska, Tej I Mehta, Horia Stefanescu, Adelina Horhat, Andreea Bumbu, Winston Dunn, Bashar Attar, Rohit Agrawal, Zohaib Syed Haque, Muhammad Majeed, Joaquín Cabezas, Inés García-Carrera, Richard Parker, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Saba Abdulsada, María Fátima Higuera-de la Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra Salazar, Lubomir Skladaný, Natália Bystrianska, Veronica Prado, Ana Clemente-Sanchez, Diego Rincón, Tehseen Haider, Kristina R Chacko, Fernando Cairo, Marcela de Sousa Coelho, Gustavo A Romero, Florencia D Pollarsky, Juan Carlos Restrepo, Susana Castro-Sanchez, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria Laura Garrido, Adrián Narvaez, Fernando Bessone, Julio Santiago Marcelo, Diego Piombino, Melisa Dirchwolf, Juan Pablo Arancibia, José Altamirano, Won Kim, Roberta C Araujo, Andrés Duarte-Rojo, Victor Vargas, Pierre-Emmanuel Rautou, Tazime Issoufaly, Felipe Zamarripa, Aldo Torre, Michael R Lucey, Philippe Mathurin, Alexandre Louvet, Guadalupe García-Tsao, José Alberto González, Elizabeth Verna, Robert S Brown, Juan Pablo Roblero, Juan G Abraldes, Marco Arrese, Vijay H Shah, Patrick S Kamath, Ashwani K Singal, Ramon Bataller
发表日期
2021/11/1
期刊
Journal of hepatology
卷号
75
期号
5
页码范围
1026-1033
出版商
Elsevier
简介
Background & Aims
Corticosteroids are the only effective therapy for severe alcohol-associated hepatitis (AH), defined by a model for end-stage liver disease (MELD) score >20. However, there are patients who may be too sick to benefit from therapy. Herein, we aimed to identify the range of MELD scores within which steroids are effective for AH.
Methods
We performed a retrospective, international multicenter cohort study across 4 continents, including 3,380 adults with a clinical and/or histological diagnosis of AH. The main outcome was mortality at 30 days. We used a discrete-time survival analysis model, and MELD cut-offs were established using the transform-the-endpoints method.
Results
In our cohort, median age was 49 (40–56) years, 76.5% were male, and 79% had underlying cirrhosis. Median MELD at admission was 24 (19–29). Survival was 88% (87–89) at 30 days, 77% (76–78) at 90 days, and 72% (72 …
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JP Arab, LA Díaz, N Baeza, F Idalsoaga… - Journal of hepatology, 2021