作者
Joe B Putnam Jr, Richard W Light, R Michael Rodriguez, Ronald Ponn, Jemi Olak, Jeffrey S Pollak, Robert B Lee, D Keith Payne, Geoff Graeber, Kevin L Kovitz
发表日期
1999/11/15
期刊
Cancer
卷号
86
期号
10
页码范围
1992-1999
出版商
John Wiley & Sons, Inc.
简介
BACKGROUND
The purpose of this study was to compare the effectiveness and safety of a chronic indwelling pleural catheter with doxycycline pleurodesis via tube thoracostomy in the treatment of patients with recurrent symptomatic malignant pleural effusions (MPE).
METHODS
In this multi‐institutional study conducted between March 1994 and February 1997, 144 patients (61 men and 83 women) were randomized in a 2:1 distribution to either an indwelling pleural catheter or doxycycline pleurodesis. Patients receiving the indwelling catheter drained their effusions via vacuum bottles every other day or as needed for relief of dyspnea.
RESULTS
The median hospitalization time was 1.0 day for the catheter group and 6.5 days for the doxycycline group. The degree of symptomatic improvement in dyspnea and the quality of life was comparable in each group. Six of 28 patients who received doxycycline (21 …
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