作者
Eranga N Vithana, Chiea-Chuen Khor, Chunyan Qiao, Monisha E Nongpiur, Ronnie George, Li-Jia Chen, Tan Do, Khaled Abu-Amero, Chor Kai Huang, Sancy Low, Liza-Sharmini A Tajudin, Shamira A Perera, Ching-Yu Cheng, Liang Xu, Hongyan Jia, Ching-Lin Ho, Kar Seng Sim, Ren-Yi Wu, Clement CY Tham, Paul TK Chew, Daniel H Su, Francis T Oen, Sripriya Sarangapani, Nagaswamy Soumittra, Essam A Osman, Hon-Tym Wong, Guangxian Tang, Sujie Fan, Hailin Meng, Dao TL Huong, Hua Wang, Bo Feng, Mani Baskaran, Balekudaru Shantha, Vedam L Ramprasad, Govindasamy Kumaramanickavel, Sudha K Iyengar, Alicia C How, Kelvin Y Lee, Theru A Sivakumaran, Victor HK Yong, Serena ML Ting, Yang Li, Ya-Xing Wang, Wan-Ting Tay, Xueling Sim, Raghavan Lavanya, Belinda K Cornes, Ying-Feng Zheng, Tina T Wong, Seng-Chee Loon, Vernon KY Yong, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, R Rand Allingham, Michael A Hauser, Dennis SC Lam, Martin L Hibberd, Shomi S Bhattacharya, Mingzhi Zhang, Yik Ying Teo, Donald T Tan, Jost B Jonas, E-Shyong Tai, Seang-Mei Saw, Do Nhu Hon, Saleh A Al-Obeidan, Jianjun Liu, Tran Nguyen Bich Chau, Cameron P Simmons, Jin-Xin Bei, Yi-Xin Zeng, Paul J Foster, Lingam Vijaya, Tien-Yin Wong, Chi-Pui Pang, Ningli Wang, Tin Aung
发表日期
2012/10
期刊
Nature genetics
卷号
44
期号
10
页码范围
1142-1146
出版商
Nature Publishing Group US
简介
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10−12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10−10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10−9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
学术搜索中的文章
EN Vithana, CC Khor, C Qiao, ME Nongpiur, R George… - Nature genetics, 2012