作者
Florina Uzefovsky, Richard AI Bethlehem, Simone Shamay-Tsoory, Amber Ruigrok, Rosemary Holt, Michael Spencer, Lindsay Chura, Varun Warrier, Bhismadev Chakrabarti, Ed Bullmore, John Suckling, Dorothea Floris, Simon Baron-Cohen
发表日期
2019/12
期刊
Molecular autism
卷号
10
页码范围
1-13
出版商
BioMed Central
简介
Background
Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor (OXTR). The current study combined genetic and brain imaging (fMRI) data to examine the moderating effect of genotype on the association between diagnosis and brain activity in response to a test of cognitive empathy.
Methods
Participants were adolescents (mean age = 14.7 ± 1.7) who were genotyped for single nucleotide polymorphisms (SNPs) within the OXTR and underwent functional brain imaging while completing the adolescent version of the ‘Reading the Mind in the Eyes’ Test (Eyes Test).
Results
Two (rs2254298, rs53576) of the five OXTR SNPs examined were significantly …
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F Uzefovsky, RAI Bethlehem, S Shamay-Tsoory… - Molecular autism, 2019
