作者
Jonas Schiffmann, Pierre I Karakiewicz, Michael Rink, L Manka, Georg Salomon, Derya Tilki, Lars Budäus, Raisa Pompe, Sami-Ramzi Leyh-Bannurah, Alexander Haese, P Hammerer, Hartwig Huland, Markus Graefen, Pierre Tennstedt
发表日期
2018/7
期刊
World journal of urology
卷号
36
页码范围
1067-1072
出版商
Springer Berlin Heidelberg
简介
Introduction
Obesity might negatively affect prostate cancer (PCa) outcomes. However, evidence according to the associations between obesity and metastases-free survival after radical prostatectomy (RP) is still inconsistent.
Methods
We relied on PCa patients treated with RP at the Martini-Klinik Prostate Cancer Center between 2004 and 2015. First, multivariable Cox regression analyses examined the impact of obesity on metastases after RP. Last, in a propensity score matched cohort, Kaplan–Meier analyses assessed metastases-free survival according to body mass index (kg/m2) (BMI) strata (≥ 30 vs. < 25).
Results
Of 13,667 individuals, 1990 (14.6%) men were obese (BMI ≥ 30). Median follow-up was 36.4 month (IQR 13.3–60.8). Obese patients were less likely to exhibit metastases after RP (HR 0.7, 95% CI 0.5 …
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J Schiffmann, PI Karakiewicz, M Rink, L Manka… - World journal of urology, 2018