作者
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Jennie Jing, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
发表日期
2016/2/1
期刊
Mayo Clinic Proceedings
卷号
91
期号
2
页码范围
196-207
出版商
Elsevier
简介
Objective
To investigate the association of estimated glomerular filtration rate (eGFR) slopes before dialysis initiation with cause-specific mortality after dialysis initiation.
Patients and Methods
In this retrospective cohort study of 18,874 US veterans who had transitioned to dialysis from October 1, 2007, through September 30, 2011, we examined the association of pre–end-stage renal disease (ESRD) eGFR slopes with all-cause, cardiovascular, and infection-related mortality during the post-ESRD period over a median follow-up of 2.0 years (interquartile range, 1.1-3.2 years). Associations were examined using Cox models with adjustment for potential confounders.
Results
Before the 18,874 patients transitioned to dialysis, 4485 (23.8%), 5633 (29.8%), and 7942 (42.1%) experienced fast, moderate, and slow eGFR decline, respectively, and 814 (4.3%) had increasing eGFR (defined as eGFR slopes of less than −10 …
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K Sumida, MZ Molnar, PK Potukuchi, F Thomas, JL Lu… - Mayo Clinic Proceedings, 2016