作者
Misagh Alipour, Deenaz Zaidi, Rosica Valcheva, Juan Jovel, Inés Martínez, Consolato Sergi, Jens Walter, Andrew L Mason, Gane Ka-Shu Wong, Levinus A Dieleman, Matthew W Carroll, Hien Q Huynh, Eytan Wine
发表日期
2016/4/1
期刊
Journal of Crohn's and Colitis
卷号
10
期号
4
页码范围
462-471
出版商
Oxford University Press
简介
Background and Aims
Ulcerative colitis [UC] is associated with colonic mucosa barrier defects and bacterial dysbiosis, but these features may simply be the result of inflammation. Therefore, we sought to assess whether these features are inherently abrogated in the terminal ileum [TI] of UC patients, where inflammation is absent.
Methods
TI biopsies from paediatric inflammatory bowel disease [IBD] subsets [Crohn’s disease [CD; n = 13] and UC [ n = 10]], and non-IBD disease controls [ n = 12] were histologically graded, and alcian blue/periodic acid-Schiff stained biopsies were quantified. The mucosal barrier was assessed for mucin [MUC2], immunoglobulin [Ig]A, IgG, and total bacteria (fluorescence in-situ hybridisation [FISH probe EUB338]) by immunofluorescence. The regulation of mucin secretion …
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M Alipour, D Zaidi, R Valcheva, J Jovel, I Martínez… - Journal of Crohn's and Colitis, 2016