作者
Danesh Moradigaravand, Veronique Martin, Sharon J Peacock, Julian Parkhill
发表日期
2017/3/8
期刊
MBio
卷号
8
期号
1
页码范围
10.1128/mbio. 01976-16
出版商
American Society for Microbiology
简介
Klebsiella pneumoniae is a human commensal and opportunistic pathogen that has become a leading causative agent of hospital-based infections over the past few decades. The emergence and global expansion of hypervirulent and multidrug-resistant (MDR) clones of K. pneumoniae have been increasingly reported in community-acquired and nosocomial infections. Despite this, the population genomics and epidemiology of MDR K. pneumoniae at the national level are still poorly understood. To obtain insights into these, we analyzed a systematic large-scale collection of invasive MDR K. pneumoniae isolates from hospitals across the United Kingdom and Ireland. Using whole-genome phylogenetic analysis, we placed these in the context of previously sequenced K. pneumoniae populations from geographically diverse countries and identified their virulence and drug resistance determinants. Our results …
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D Moradigaravand, V Martin, SJ Peacock, J Parkhill - MBio, 2017