作者
Danesh Moradigaravand, Christine J Boinett, Veronique Martin, Sharon J Peacock, Julian Parkhill
发表日期
2016/8/1
期刊
Genome research
卷号
26
期号
8
页码范围
1101-1109
出版商
Cold Spring Harbor Lab
简介
Serratia marcescens, a member of the Enterobacteriaceae family, is a Gram-negative bacterium responsible for a wide range of nosocomial infections. The emergence of multidrug-resistant strains is an increasing danger to public health. To design effective means to control the dissemination of S. marcescens, an in-depth analysis of the population structure and variation is required. Utilizing whole-genome sequencing, we characterized the population structure and variation, as well as the antimicrobial resistance determinants, of a systematic collection of antimicrobial-resistant S. marcescens associated with bloodstream infections in hospitals across the United Kingdom and Ireland between 2001 and 2011. Our results show that S. marcescens is a diverse species with a high level of genomic variation. However, the collection was largely composed of a limited number of clones that emerged from this diverse …
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D Moradigaravand, CJ Boinett, V Martin, SJ Peacock… - Genome research, 2016