作者
Sara Bandres‐Ciga, Sara Saez‐Atienzar, Luis Bonet‐Ponce, Kimberley Billingsley, Dan Vitale, Cornelis Blauwendraat, Jesse Raphael Gibbs, Lasse Pihlstrøm, Ziv Gan‐Or, International Parkinson's Disease Genomics Consortium (IPDGC), Alastair J Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Demis A Kia, Manuela Tan, Henry Houlden, Huw R Morris, Helene Plun‐Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, Jose Bras, John Quinn, Kin Y Mok, Kerri J Kinghorn, Kimberley Billingsley, Nicholas W Wood, Patrick Lewis, Sebastian Schreglmann, Rita Guerreiro, Ruth Lovering, Lea RņBibo, Claudia Manzoni, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott‐Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Karen E Morrison, Alexis Brice, Fabrice Danjou, Suzanne Lesage, Jean‐Christophe Corvol, Maria Martinez, Claudia Schulte, Kathrin Brockmann, Javier SimɃn‐Sȥnchez, Peter Heutink, Patrizia Rizzu, Manu Sharma, Thomas Gasser, Aude Nicolas, Mark R Cookson, Sara Bandres‐Ciga, Cornelis Blauwendraat, David W Craig, Faraz Faghri, J Raphael Gibbs, Dena G Hernandez, Kendall Van Keuren‐Jensen, Joshua M Shulman, Hirotaka Iwaki, Hampton L Leonard, Mike A Nalls, Laurie Robak, Steven Lubbe, Steven Finkbeiner, Niccolo E Mencacci, Codrin Lungu, Andrew B Singleton, Sonja W Scholz, Xylena Reed, Roy N Alcalay, Ziv Gan‐Or, Guy A Rouleau, Jacobus J van Hilten, Johan Marinus, Astrid D Adarmes‐GɃmez, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Francisco Javier Barrero, Jesɐs Alberto Bergareche Yarza, Inmaculada Bernal‐Bernal, Marta Blazquez, Marta Bonilla‐Toribio, Juan A Botȷa, Marȷa Teresa Boungiorno, Dolores Buiza‐Rueda, Ana Cȥmara, Fȥtima Carrillo, Mario CarriɃn‐Claro, Debora Cerdan, Jordi ClarimɃn, Yaroslau Compta, Beatrȷz de la Casa, Monica Diez‐Fairen, Oriol Dols‐Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla‐Sevilla, Mario Ezquerra, Cici Feliz, Manel Fernȥndez, Rubȳn Fernȥndez‐Santiago, Ciara Garcia, Pedro Garcȷa‐Ruiz, Pilar GɃmez‐Garre, Maria Jose Gomez Heredia, Isabel Gonzalez‐Aramburu, Ana Gorostidi Pagola, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez‐Escrig, Jaime Kulisevsky, Miguel A Labrador‐Espinosa, Jose Luis Lopez‐Sendon, Adolfo LɃpez de Munain Arregui, Daniel Macias, Irene Martȷnez Torres, Juan Marȷn, Maria Jose Marti, Juan Carlos Martȷnez‐Castrillo, Carlota Mȳndez‐del‐Barrio, Manuel Menȳndez Gonzȥlez, Marina Mata, Adolfo Mȷnguez, Pablo Mir, Elisabet Mondragon Rezola, Esteban MuɁoz, Javier Pagonabarraga, Berta Pascual‐Sedano, Pau Pastor, Francisco Perez Errazquin, Teresa PeriɁȥn‐Tocino, Javier Ruiz‐Martȷnez, Clara Ruz, Antonio Sanchez Rodriguez, Marȷa Sierra, Esther Suarez‐Sanmartin, Cesar Tabernero, Juan Pablo Tartari, Cristina Tejera‐Parrado, Eduard Tolosa, Francesc Valldeoriola, Laura Vargas‐Gonzȥlez, Lydia Vela
发表日期
2019/4
期刊
Movement Disorders
卷号
34
期号
4
页码范围
460-468
出版商
John Wiley & Sons, Inc.
简介
Background
PD is a complex polygenic disorder. In recent years, several genes from the endocytic membrane‐trafficking pathway have been suggested to contribute to disease etiology. However, a systematic analysis of pathway‐specific genetic risk factors is yet to be performed.
Objectives
To comprehensively study the role of the endocytic membrane‐trafficking pathway in the risk of PD.
Methods
Linkage disequilibrium score regression was used to estimate PD heritability explained by 252 genes involved in the endocytic membrane‐trafficking pathway including genome‐wide association studies data from 18,869 cases and 22,452 controls. We used pathway‐specific single‐nucleotide polymorphisms to construct a polygenic risk score reflecting the cumulative risk of common variants. To prioritize genes for follow‐up functional studies, summary‐data based Mendelian randomization analyses were applied to …
学术搜索中的文章
S Bandres‐Ciga, S Saez‐Atienzar, L Bonet‐Ponce… - Movement Disorders, 2019
