作者
Kausik Bishayee, Sourav Sikdar, Anisur Rahman Khuda-Bukhsh
发表日期
2013/12
期刊
J Pharmacopuncture
卷号
16
期号
4
页码范围
7-13
出版商
Korean Pharmacopuncture Institute
简介
Objectives:
Whether the ultra-highly-diluted remedies used in homeopathy can effectively bring about modulations of gene expressions through acetylation/deacetylation of histones has not been explored. Therefore, in this study, we pointedly checked if the homeopathically-diluted anti-cancer remedy Condurango 30C (ethanolic extract of Gonolobus condurango diluted 10-60 times) was capable of arresting the cell cycles in cervical cancer cells HeLa by triggering an epigenetic modification through modulation of the activity of the key enzyme histone deacetylase 2 vis-a-vis the succussed alcohol (placebo) control.
Methods:
We checked the activity of different signal proteins (like p21 WAF, p53, Akt, STAT3) related to deacetylation, cell growth and differentiation by western blotting and analyzed cell-cycle arrest, if any, by fluorescence activated cell sorting. After viability assays had been performed with Condurango …
学术搜索中的文章
K Bishayee, S Sikdar, AR Khuda-Bukhsh - Journal of pharmacopuncture, 2013
K Bishayee, S Sikdar, AR Khuda-Bukhsh - J Pharmacopunctue, 2013