作者
Elizabeth Nance, Siva P Kambhampati, Elizabeth S Smith, Zhi Zhang, Fan Zhang, Sarabdeep Singh, Michael V Johnston, Rangaramanujam M Kannan, Mary E Blue, Sujatha Kannan
发表日期
2017/12
期刊
Journal of neuroinflammation
卷号
14
页码范围
1-19
出版商
BioMed Central
简介
Background
Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain inflammation/injury both in vitro and in vivo using a Mecp2-null mouse model of Rett syndrome.
Methods
To determine whether inflammation and immune dysregulation were potential targets for dendrimer-based therapeutics in RTT, we assessed the immune response of primary glial cells from Mecp2-null and wild-type (WT) mice to LPS. Using dendrimers that intrinsically target activated microglia and astrocytes, we studied N-acetyl cysteine (NAC) and …
学术搜索中的文章
E Nance, SP Kambhampati, ES Smith, Z Zhang… - Journal of neuroinflammation, 2017