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A colorimetric chemosensor for hydrogen peroxide (H₂O₂) and biosensor for cholesterol is developed in this work following a ‘label-free and reagentless’ concept. In this strategy, silver nanoparticles (AgNPs) are used as a bifunctional probe, namely, a chemical capture probe for H₂O₂ recognition and a signal probe for displaying detection results. The working principle of these colorimetric sensors is based on the redox reaction between AgNPs and H₂O₂. This reaction converts AgNPs into Ag⁺ ions, which can induce a visible color change from yellow to pinkish or colorless depending on the amount of H₂O₂. Therefore, H₂O₂ concentration can be measured. The developed colorimetric H₂O₂ chemosensor exhibits a highly selective and sensitive property towards H₂O₂ with a limit of detection (LOD) of 3.5 μM. Subsequently, a colorimetric biosensor is developed for cholesterol detection by combining AgNPs and …