作者
John W Steele, Sharon Bayliss, John Bayliss, Ying Linda Lin, Bogdan J Wlodarczyk, Robert M Cabrera, Yohannes G Asfaw, Thomas J Cummings, Richard H Finnell, Timothy M George
发表日期
2020/3/1
期刊
Journal of pediatric surgery
卷号
55
期号
3
页码范围
475-481
出版商
WB Saunders
简介
Background/Purpose
In 2004, a heritable occurrence of spina bifida was reported in sheep on a farm in the United States. We maintained and characterized the spina bifida phenotype in this flock to assess its potential as an alternative surgical model.
Methods
A breeding strategy was developed in which the sheep were crossed to maintain or increase the occurrence of spina bifida. Measurements and observations were recorded regarding lesion size, birthweight, ambulatory capacity, or urological function, and necropsies were performed on spina bifida afflicted lambs in conjunction with magnetic resonance imaging to determine the character of the spina bifida defects and assess the presence of Chiari-like malformations or hydrocephalus.
Results
The defects were observed to be more prevalent in ram lambs, and the rate of spina bifida per litter could be increased through backcrossing or by selection of a …
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JW Steele, S Bayliss, J Bayliss, YL Lin, BJ Wlodarczyk… - Journal of pediatric surgery, 2020