查看文章

Dear Editor, It is well established that folic acid (FA) supplementation can significantly reduce the risk of birth defects, including neural tube defects (NTDs) 1 and congenital heart defects (CHDs) 2. More than 80 nations have adopted mandatory FA food fortification programs 3. With additional FA intake from different dietary supplements, a portion of the population is exposed to FA concentrations over the 0.4 mg recommended daily allowance (RDA) 4. These people include women who had a prior NTD complicated pregnancy and are planning to start a new pregnancy 5, and men with fertility issues who are treated with high-dose FA (12.5 times of RDA) supplementation to improve sperm counts 6. However, there is a lack of research on whether excessive FA intake has the potential to harm human beings. Recently, a case with “pseudo-MTHFR” syndrome was reported, a wild-type MTHFR Caucasian woman with a …