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Heat-stabilized rice bran is a nutrient-dense food ingredient that has shown colorectal cancer control and prevention properties in a suite of carcinogen-induced animal models. This study identified colon cancer protective properties associated with rice bran metabolism in feces that relate to the previously reported findings in gastrointestinal tissue. A longitudinal analysis of fecal microbiota and metabolite changes between diet treatments identified novel mechanisms for rice bran-mediated anti-cancer activity. Fecal metabolites in response to dietary rice bran intake in mice showed overlap with results from adult colorectal cancer survivors after eating rice bran. These molecules may serve as translational dietary biomarkers for colorectal cancer prevention.

Dietary rice bran-mediated inhibition of colon carcinogenesis was demonstrated previously for carcinogen-induced rodent models via multiple anti-cancer mechanisms. This study investigated the role of dietary rice bran-mediated changes to fecal microbiota and metabolites over the time course of colon carcinogenesis and compared murine fecal metabolites to human stool metabolic profiles following rice bran consumption by colorectal cancer survivors (NCT01929122). Forty adult male BALB/c mice were subjected to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated colon carcinogenesis and randomized to control AIN93M (n = 20) or diets containing 10% w/w heat-stabilized rice bran (n = 20). Feces were serially collected for 16S rRNA amplicon sequencing and non-targeted metabolomics. Fecal …