作者
Francesco Del Sole, Alessio Farcomeni, Lorenzo Loffredo, Roberto Carnevale, Danilo Menichelli, Tommasa Vicario, Pasquale Pignatelli, Daniele Pastori
发表日期
2020/10
来源
European journal of clinical investigation
卷号
50
期号
10
页码范围
e13378
简介
Background
To systematically review clinical and biochemical characteristics associated with the severity of the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐related disease (COVID‐19).
Materials and methods
Systematic review of observational studies from PubMed, ISI Web of Science, SCOPUS and Cochrane databases including people affected by COVID‐19 and reporting data according to the severity of the disease. Data were combined with odds ratio (OR) and metanalysed. Severe COVID‐19 was defined by acute respiratory distress syndrome, intensive care unit admission and death.
Results
We included 12 studies with 2794 patients, of whom 596 (21.33%) had severe disease. A slightly higher age was found in severe vs non‐severe disease. We found that prevalent cerebrovascular disease (odds ratio [OR] 3.66, 95% confidence interval [CI] 1.73‐7.72), chronic obstructive …
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F Del Sole, A Farcomeni, L Loffredo, R Carnevale… - European journal of clinical investigation, 2020