作者
Tiina Jääskeläinen, Olli Kärkkäinen, Jenna Jokkala, Anton Klåvus, Seppo Heinonen, Seppo Auriola, Marko Lehtonen, FINNPEC Core Investigator Group Eero Kajantie Juha Kere Katja Kivinen Anneli Pouta, Kati Hanhineva, Hannele Laivuori
发表日期
2021/2
期刊
Metabolomics
卷号
17
页码范围
1-12
出版商
Springer US
简介
Introduction
Maternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation.
Objectives and methods
We applied liquid chromatography–mass spectrometry (LC–MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy.
Results
Progression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The …
学术搜索中的文章
T Jääskeläinen, O Kärkkäinen, J Jokkala, A Klåvus… - Metabolomics, 2021