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This is the first in a series of articles that explore herbs and drug resistance. In Part 1, the authors discuss the general phenomeon of antibiotic resistance and review studies showing that herbs may have a positive effect on microbial resistance to antibiotics. In Part 2, the authors will evaluate this research and discuss its clinical implications. Subsequent articles will cover herbs and resistance of cancer cells to chemotherapy and provide more detailed information about the mechanisms of drug resistance and how herbs affect them.