作者
Małgorzata Pucułek, Julita Machlowska, Ryszard Wierzbicki, Jacek Baj, Ryszard Maciejewski, Robert Sitarz
发表日期
2018/7/7
来源
Oncotarget
卷号
9
期号
57
页码范围
31146
出版商
Impact Journals, LLC
简介
Nowadays, gastric cancer is one of the most common neoplasms and the fourth cause of cancer-related death on the world. Regarding the age at the diagnosis it is divided into early-onset gastric carcinoma (45 years or younger) and conventional gastric cancer (older than 45). Gastric carcinomas are rarely observed in young population and rely mostly on genetic factors, therefore provide the unique model to study genetic and environmental alternations. The latest research on early-onset gastric cancer are trying to explain molecular and genetic basis, because young patients are less exposed to environmental factors predisposing to cancer. In the general population, Helicobacter pylori, has been particularly associated with intestinal subtype of gastric cancers. The significant association of Helicobacter pylori infection in young patients with gastric cancers suggests that the bacterium has an etiologic role in both …
学术搜索中的文章
M Pucułek, J Machlowska, R Wierzbicki, J Baj… - Oncotarget, 2018