作者
Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, John C Hartley, Michaela Brown, Joanne Dalton, Tom Kearns, Tracy Moitt, Michael J Griffiths, Giovanna Culeddu, Tom Solomon, Dyfrig Hughes, Carrol Gamble, Benedetta Pettorini, Christopher Parks, Ajay Sinha, Libby van Tonder, Mitchel T Foster, Catherine McMahon, Neil Buxton, Emmanuel Chavredakis, Andrew R Brodbelt, David DA Lawson, Paul R Eldridge, Jibril O Farah, Rasheed Zakaria, Sunderland Geraint, Guirish Solanki, Desiderio Rodrigues, Richard Edwards, Adam Williams, Matthew Garnett, Angelos Kolias, Peter JA Hutchinson, Karen Caldwell, Silvia Tarantino, Paul Leach, Malik Zaben, Gulam Zilani, Dmitri Shastin, Joseph Merola, Rahim Hussain, Ravindra Vemaraju, Liudmila Selezneva, Georgina Radford, Nadine Lloyd, Darach Crimmins, John Caird, Maria N Sayar, Noelle O'Mahoney, Dominic Thompson, Kristian Aquilina, Gregory James, Roger Strachan, Nitin Mukerji, Bassel Zebain, Bhaskar Thakur, Holly Dickson, Eniola Nsirim, Adedamola Adebayo, John Goodden, Kenan Deniz, Janet Clarke, Mary Kambafwile, Ian Anderson, Rebecca Chave-Cox, Asim Sheik, Ryan Mathew, Oliver Richards, Soumya Mukherjee, Paul Chumas, Atul Tyagi, Gnanamurthy Sikakumar, Admed Toma, Linda D'Antona, Laurence Watkins, Lewis Thorne, Claudia Craven, Vanessa Bassen, Damien Holliman, Ian Coulter, Donald Macarthur, Maria Cartmill, Simon Howarth, Stuart Smith, Shazia Javed, Ian Kamaly, Roberto Ramirez, Andrew King, Ardash Nadig, John Thorne, Shungu Ushewokunze, Saurabh Sinha, Hesham Zaki, John McMullan, Diederik Bulters, Ryan Waters, George Zilidis, Joy Roach, Ahmed Sadek, Patrick Holton, Ardalan Zolnourian, Aabir Chakraborty, Jothy Kandasamy, Mark Hughes, Paul M Brennan
发表日期
2019/10/26
期刊
The Lancet
卷号
394
期号
10208
页码范围
1530-1539
出版商
Elsevier
简介
Background
Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures worldwide. Infection of the implanted shunt affects up to 15% of these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition and quality of life. Our aim was to determine the clinical and cost-effectiveness of antibiotic (rifampicin and clindamycin) or silver shunts compared with standard shunts at reducing infection.
Methods
In this parallel, multicentre, single-blind, randomised controlled trial, we included patients with hydrocephalus of any aetiology undergoing insertion of their first ventriculoperitoneal shunt irrespective of age at 21 regional adult and paediatric neurosurgery centres in the UK and Ireland. Patients were randomly assigned (1:1:1 in random permuted blocks of three or six) to receive standard shunts (standard shunt group), antibiotic …
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CL Mallucci, MD Jenkinson, EJ Conroy, JC Hartley… - The Lancet, 2019