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Cardiac resynchronization therapy (CRT) with or without a defibrillator has a positive effect on mortality and morbidity for patients with heart failure. However, comparisons between CRT‐defibrillators (CRT‐D) and CRT‐pacemakers (CRT‐P) are relatively scarce outside the clinical trial setting. This study aimed to assess baseline characteristics in relation to long‐term prognosis in patients treated with CRT, and to investigate the potential benefit of CRT‐D versus CRT‐P.

Data were retrospectively collected from the medical records of all consecutive patients treated with CRT‐P or primary prophylactic CRT‐D at a large tertiary care center between 1999 and 2012. Predictors of mortality were investigated, and time‐dependent analysis was performed with all‐cause mortality as the primary end point.

A total of 705 patients were included (69.6 ± 10 years, 78% New York Heart Association …