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Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of K₂CO₃. The chemical structures of the compounds were elucidated by IR,¹H-NMR, and FAB⁺-MS spectral data. Their antimicrobial activities againstMicrococcus luteus (NRLL B-4375),Bacillus cereus (NRRL B-3711),Proteus vulgaris (NRRL B-123),Salmonella typhimurium (NRRL B-4420),Staphylococcus aureus (NRRL B-767),Escherichia coli (NRRL B-3704),Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.