作者
Mark O Goodarzi, Daniel A Dumesic, Gregorio Chazenbalk, Ricardo Azziz
发表日期
2011/4
来源
Nature reviews endocrinology
卷号
7
期号
4
页码范围
219-231
出版商
Nature Publishing Group
简介
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with a prevalence of up to 10%. Various diagnostic criteria have been proposed, generally centered around the features of hyperandrogenism and/or hyperandrogenemia, oligo-ovulation and polycystic ovarian morphology. Insulin resistance is present in a majority of cases, with compensatory hyperinsulinemia contributing to hyperandrogenism via stimulation of ovarian androgen secretion and inhibition of hepatic sex hormone-binding globulin production. Adipose tissue dysfunction has been implicated as a contributor to the insulin resistance observed in PCOS. Environmental and genetic factors also have a role in the development of PCOS. The syndrome is associated with numerous morbidities, including infertility, obstetrical complications, type 2 diabetes mellitus, cardiovascular disease, and mood and …
引用总数
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学术搜索中的文章
MO Goodarzi, DA Dumesic, G Chazenbalk, R Azziz - Nature reviews endocrinology, 2011