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Context: Polycystic ovary syndrome (PCOS), the most common cause of anovulatory infertility, is characterized by increased ovarian androgen production and arrested follicle development and is frequently associated with insulin resistance. These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss.

Objective: The objective of this study was to examine whether the perturbations in follicle growth and the intrafollicular environment affect gene expression and ultimately development of the PCOS oocyte.

Design: Oocyte cDNA was subjected to microarray and PCR analysis.

Setting: This study was conducted at a university laboratory.

Patients: The study comprised 10 normal ovulatory women and nine women with PCOS.

Intervention: The intervention was GnRH analog/recombinant human …