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The complement system, as a vital part of innate immunity, has an important role in the clearance of pathogens; however, unregulated activation of this system probably has a key role in the pathogenesis of acute lung injury, which is induced by highly pathogenic viruses (i.e. influenza A viruses and severe acute respiratory syndrome [SARS] coronavirus). The novel coronavirus SARS‐CoV‐2, which is the causal agent for the ongoing global pandemic of the coronavirus disease 2019 (Covid‐19), has recently been spread to almost all countries around the world. Although most people are immunocompetent to SARS‐CoV‐2, a small group develops hyper‐inflammation that leads to complications like acute respiratory distress syndrome, disseminated intravascular coagulation, and multi‐organ failure. Emerging evidence demonstrates that the complement system exerts a crucial role in this inflammatory reaction …