作者
Norbert Galldiks, Marion Rapp, Gabriele Stoffels, Gereon R Fink, Nadim J Shah, Heinz H Coenen, Michael Sabel, Karl-Josef Langen
发表日期
2013/1
期刊
European journal of nuclear medicine and molecular imaging
卷号
40
页码范围
22-33
出版商
Springer-Verlag
简介
Purpose
To investigate prospectively the potential of O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) PET in comparison to MRI for the assessment of the response of patients with recurrent high-grade glioma (rHGG) to antiangiogenic treatment.
Methods
Ten patients with rHGG were treated biweekly with bevacizumab/irinotecan (BEV/IR). MR images and dynamic 18F-FET PET scans were obtained at baseline and at follow-up after the start of treatment (median 4.9 weeks). Using MRI treatment response was evaluated according to RANO (Response Assessment in Neuro-Oncology) criteria. For 18F-FET PET evaluation, a reduction >45 % of the metabolically active tumour volume was considered as a treatment response, with the metabolically active tumour being defined as a tumour-to-brain ratio (TBR) of ≥1.6. The results of the treatment assessments were …
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N Galldiks, M Rapp, G Stoffels, GR Fink, NJ Shah… - European journal of nuclear medicine and molecular …, 2013