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Because of the high glucose metabolism in normal brain tissue ¹⁸F-FDG is not the ideal tracer for the detection of gliomas. Methyl-¹¹C-l-methionine (¹¹C-MET) is better suited for imaging the extent of gliomas, because it is transported specifically into tumors but only insignificantly into normal brain. 3′-Deoxy-3′-¹⁸F-fluorothymidine (¹⁸F-FLT) has been introduced as a proliferation marker in a variety of neoplasias and has promising potential for the detection of brain tumors, because its uptake in normal brain is low. Additionally, the longer half-life might permit differentiation between transport and intracellular phosphorylation. PET of ¹⁸F-FLT and ¹¹C-MET was performed on 23 patients (age range, 20–70 y) with histologically verified gliomas of different grades. On all patients, conventional MRI was performed, and 16 patients additionally underwent contrast-enhanced imaging. Images were coregistered …