作者
Rita O Teodoro, Gulçin Pekkurnaz, Abdullah Nasser, Misao E Higashi‐Kovtun, Maria Balakireva, Ian G McLachlan, Jacques Camonis, Thomas L Schwarz
发表日期
2013/7/17
期刊
The EMBO journal
卷号
32
期号
14
页码范围
2039-2055
出版商
John Wiley & Sons, Ltd
简介
Remodelling neuronal connections by synaptic activity requires membrane trafficking. We present evidence for a signalling pathway by which synaptic activity and its consequent Ca2+ influx activate the small GTPase Ral and thereby recruit exocyst proteins to postsynaptic zones. In accord with the ability of the exocyst to direct delivery of post‐Golgi vesicles, constitutively active Ral expressed in Drosophila muscle causes the exocyst to be concentrated in the region surrounding synaptic boutons and consequently enlarges the membrane folds of the postsynaptic plasma membrane (the subsynaptic reticulum, SSR). SSR growth requires Ral and the exocyst component Sec5 and Ral‐induced enlargement of these membrane folds does not occur in sec5−/− muscles. Chronic changes in synaptic activity influence the plastic growth of this membrane in a manner consistent with activity‐dependent activation of Ral. Thus …
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RO Teodoro, G Pekkurnaz, A Nasser… - The EMBO journal, 2013