作者
A Pieter Kappetein, Stuart J Head, Philippe Généreux, Nicolo Piazza, Nicolas M Van Mieghem, Eugene H Blackstone, Thomas G Brott, David J Cohen, Donald E Cutlip, Gerrit-Anne van Es, Rebecca T Hahn, Ajay J Kirtane, Mitchell W Krucoff, Susheel Kodali, Michael J Mack, Roxana Mehran, Josep Rodés-Cabau, Pascal Vranckx, John G Webb, Stephan Windecker, Patrick W Serruys, Martin B Leon
发表日期
2013/1/1
来源
The Journal of thoracic and cardiovascular surgery
卷号
145
期号
1
页码范围
6-23
出版商
Mosby
简介
OBJECTIVES
The aim of the current Valve Academic Research Consortium (VARC)-2 initiative was to revisit the selection and definitions of transcatheter aortic valve implantation (TAVI) clinical endpoints to make them more suitable to the present and future needs of clinical trials. In addition, this document is intended to expand the understanding of patient risk stratification and case selection.
BACKGROUND
A recent study confirmed that VARC definitions have already been incorporated into clinical and research practice and represent a new standard for consistency in reporting clinical outcomes of patients with symptomatic severe aortic stenosis (AS) undergoing TAVI. However, as the clinical experience with this technology has matured and expanded, certain definitions have become unsuitable or ambiguous.
METHODS AND RESULTS
Two in-person meetings (held in September 2011 in Washington, DC, and …
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AP Kappetein, SJ Head, P Généreux, N Piazza… - The Journal of thoracic and cardiovascular surgery, 2013