作者
ML Malosio, B Marqueze‐Pouey, J Kuhse, H Betz
发表日期
1991/9/1
期刊
The EMBO journal
卷号
10
期号
9
页码范围
2401-2409
简介
The inhibitory glycine receptor (GlyR) is a ligand‐gated ion channel which mediates post‐synaptic inhibition in spinal cord and other regions of the vertebrate central nervous system. Previous biochemical and molecular cloning studies have indicated heterogeneity of GlyRs during development. Here, the distribution of GlyR subunit transcripts in rat brain and spinal cord was investigated by in situ hybridization using sequence‐specific oligonucleotide probes. In adult animals, GlyR alpha 1 subunit mRNA was abundant in spinal cord, but was also seen in a few brain areas, e.g. superior and inferior colliculi, whereas alpha 2 transcripts were found in several brain regions including layer VI of the cerebral cortex and hippocampus. GlyR alpha 3 subunit mRNA was expressed at low levels in cerebellum, olfactory bulb and hippocampus, while high amounts of beta subunit transcripts were widely distributed throughout …
引用总数
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ML Malosio, B Marqueze‐Pouey, J Kuhse, H Betz - The EMBO journal, 1991