作者
Meghan R Swanson, Mark D Shen, Jason J Wolff, Jed T Elison, Robert W Emerson, Martin A Styner, Heather C Hazlett, Kinh Truong, Linda R Watson, Sarah Paterson, Natasha Marrus, Kelly N Botteron, Juhi Pandey, Robert T Schultz, Stephen R Dager, Lonnie Zwaigenbaum, Annette M Estes, Joseph Piven, J Piven, HC Hazlett, C Chappell, S Dager, AM Estes, D Shaw, K Botteron, R McKinstry, J Constantino, J Pruett, RT Schultz, J Pandey, S Paterson, L Zwaigenbaum, JT Elison, JJ Wolff, AC Evans, DL Collins, GB Pike, V Fonov, P Kostopoulos, S Das, G Gerig, M Styner, H Gu
发表日期
2017/11/1
期刊
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
卷号
2
期号
8
页码范围
664-672
出版商
Elsevier
简介
Background
Younger siblings of children with autism spectrum disorder (ASD) are themselves at increased risk for ASD and other developmental concerns. It is unclear if infants who display developmental concerns, but are unaffected by ASD, share similar or dissimilar behavioral and brain phenotypes to infants with ASD. Most individuals with ASD exhibit heterogeneous difficulties with language, and their receptive-expressive language profiles are often atypical. Yet, little is known about the neurobiology that contributes to these language difficulties.
Methods
In this study, we used behavioral assessments and structural magnetic resonance imaging to investigate early brain structures and associations with later language skills. High-risk infants who were later diagnosed with ASD (n = 86) were compared with high-risk infants who showed signs of early language delay (n = 41) as well as with high- and low-risk …
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MR Swanson, MD Shen, JJ Wolff, JT Elison… - Biological Psychiatry: Cognitive Neuroscience and …, 2017