作者
N Marrus, LP Hall, SJ Paterson, JT Elison, JJ Wolff, MR Swanson, J Parish-Morris, AT Eggebrecht, JR Pruett, HC Hazlett, L Zwaigenbaum, S Dager, AM Estes, RT Schultz, KN Botteron, J Piven, JN Constantino, IBIS Network J Piven HC Hazlett C Chappell S Dager A Estes D Shaw K Botteron R McKinstry J Constantino J Pruett RT Schultz S Paterson L Zwaigenbaum J Elison AC Evans DL Collins GB Pike V Fonov P Kostopoulos S Das G Gerig M Styner H Gu
发表日期
2018/12
期刊
Journal of neurodevelopmental disorders
卷号
10
页码范围
1-16
出版商
BioMed Central
简介
Background
Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype.
Methods
We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the …
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N Marrus, LP Hall, SJ Paterson, JT Elison, JJ Wolff… - Journal of neurodevelopmental disorders, 2018