作者
Claire J McKinnon, Adam T Eggebrecht, Alexandre Todorov, Jason J Wolff, Jed T Elison, Chloe M Adams, Abraham Z Snyder, Annette M Estes, Lonnie Zwaigenbaum, Kelly N Botteron, Robert C McKinstry, Natasha Marrus, Alan Evans, Heather C Hazlett, Stephen R Dager, Sarah J Paterson, Juhi Pandey, Robert T Schultz, Martin A Styner, Guido Gerig, Bradley L Schlaggar, Steven E Petersen, Joseph Piven, John R Pruett Jr, IBIS Network
发表日期
2019/1/1
期刊
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
卷号
4
期号
1
页码范围
50-61
出版商
Elsevier
简介
Background
Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown.
Methods
Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory.
Results
Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual …
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CJ McKinnon, AT Eggebrecht, A Todorov, JJ Wolff… - Biological Psychiatry: Cognitive Neuroscience and …, 2019