作者
Catherine A Burrows, Rebecca L Grzadzinski, Kevin Donovan, Isabella C Stallworthy, Joshua Rutsohn, Tanya St John, Natasha Marrus, Julia Parish-Morris, Leigh MacIntyre, Jacqueline Hampton, Juhi Pandey, Mark D Shen, Kelly N Botteron, Annette M Estes, Stephen R Dager, Heather C Hazlett, John R Pruett Jr, Robert T Schultz, Lonnie Zwaigenbaum, Kinh N Truong, Joseph Piven, Jed T Elison, IBIS Network
发表日期
2022/10/15
期刊
Biological psychiatry
卷号
92
期号
8
页码范围
654-662
出版商
Elsevier
简介
Background
Sex differences in the prevalence of neurodevelopmental disorders are particularly evident in autism spectrum disorder (ASD). Heterogeneous symptom presentation and the potential of measurement bias hinder early ASD detection in females and may contribute to discrepant prevalence estimates. We examined trajectories of social communication (SC) and restricted and repetitive behaviors (RRBs) in a sample of infant siblings of children with ASD, adjusting for age- and sex-based measurement bias. We hypothesized that leveraging a prospective elevated familial likelihood sample, deriving data-driven behavioral constructs, and accounting for measurement bias would reveal less discrepant sex ratios than are typically seen in ASD.
Methods
We conducted direct assessments of ASD symptoms at 6 to 9, 12 to 15, 24, and 36 to 60 months of age (total nobservations = 1254) with infant siblings of …
学术搜索中的文章
CA Burrows, RL Grzadzinski, K Donovan… - Biological psychiatry, 2022