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Drugs targeting the immune system are a promising new approach for treatment of schizophrenia. In search of methods for patient stratification, great effort has been invested into positron emission tomography studies using radioligands that bind to the 18-kDa translocator protein (TSPO), a glial cell marker, yielding seemingly inconclusive results (1–12). To address this issue, we previously conducted an individual participant data meta-analysis, pooling data from all 5 published studies at the time that employed second-generation TSPO radioligands that show superior signal-to-noise ratio compared with the first TSPO radioligand,(R)-[11C] PK11195 (13). Contrary to the originally expected hypothesis of an upregulation of TSPO, we observed strong evidence of lower total distribution volume (VT)—an index of radioligand binding to TSPO—in psychosis patients compared with healthy control subjects (14 …