作者
Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Ellen De Roeck, Sarah Ceyssens, Christine Van Broeckhoven, Sebastiaan Engelborghs, Sigrid Stroobants, Steven Staelens
发表日期
2019/9/1
期刊
Alzheimer's & Dementia
卷号
15
期号
9
页码范围
1172-1182
出版商
No longer published by Elsevier
简介
Introduction
Dual-biomarker positron emission tomography (PET), providing complementary information on cerebral blood flow and amyloid-β deposition, is of clinical interest for Alzheimer's disease (AD). The purpose of this study was to validate the perfusion components of early-phase 18F-florbetapir (eAV45), the 18F-AV45 delivery rate (R1), and 18F-FDG against 15O-H2O PET and assess how they change with disease severity.
Methods
This study included ten controls, 19 amnestic mild cognitive impairment, and 10 AD dementia subjects. Within-subject regional correlations between modalities, between-group regional and voxel-wise analyses of covariance per modality, and receiver operating characteristic analyses for discrimination between groups were performed.
Results
FDG standardized uptake value ratio, eAV45 (0–2 min) standardized uptake value ratio, and AV45-R1 were significantly associated with H …
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J Ottoy, J Verhaeghe, E Niemantsverdriet, E De Roeck… - Alzheimer's & Dementia, 2019