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In this study the protective effect of kefir against liver tissue damage at experimental Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD) was investigated. A total of 30 Wistar albino rabbit female rats were used. Rats were divided into 5 groups each group had 6 animals. Any application was done to control group animals. A single dose of 80 mg/kg intraperitoneal Streptozotocin was given to the animals to form T2DM, and a high fat rat was fed to the animals throughout the experiment to generate NAFLD. The animals in the experimental group were fed high fat rat diet, high fat rat diet+ 30 ml/kg kefir (oral gavage), high fat rat diet+ Streptozotocin 80 mg/kg intraperitoneal (IP), high fat rat diet+ 30 ml/kg kefir Oral gavage)+ Streptozotocin 80 mg/kg (IP). A decrease in blood glucose levels was observed with the addition of kefir compared to the T2DM group. Also increased serum AST, ALT, total protein, cholesterol, triglyceride levels were decreased by the addition of kefir in the T2DM and NAFLD groups. Histopathological findings also support biochemical results. In the liver of kefir-added group, close to normal histological structure was observed. As a result, it was concluded that consumption of kefir beverage would be beneficial against T2DM and NAFLD, which cause serious damage to the liver.