作者
Lydia J Leon, Fergus P McCarthy, Kenan Direk, Arturo Gonzalez-Izquierdo, David Prieto-Merino, Juan P Casas, Lucy Chappell
发表日期
2019/9/24
期刊
Circulation
卷号
140
期号
13
页码范围
1050-1060
出版商
Lippincott Williams & Wilkins
简介
Background
The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardiovascular disorders.
Methods
We used linked electronic health records from 1997 to 2016 to recreate a UK population-based cohort of 1.3 million women, mean age at delivery 28 years, with nearly 1.9 million completed pregnancies. We used multivariable Cox models to determine the associations between hypertensive disorders of pregnancy, and preeclampsia alone (term and preterm), with 12 cardiovascular disorders in addition to chronic hypertension. We estimated the cumulative incidence of a composite end point of any cardiovascular disorder according to preeclampsia …
引用总数
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