作者
Marcus R Munafò, Maria N Timofeeva, Richard W Morris, David Prieto-Merino, Naveed Sattar, Paul Brennan, Elaine C Johnstone, Caroline Relton, Paul CD Johnson, Donna Walther, Peter H Whincup, Juan P Casas, George R Uhl, Paolo Vineis, Sandosh Padmanabhan, Barbara J Jefferis, Antoinette Amuzu, Elio Riboli, Mark N Upton, Paul Aveyard, Shah Ebrahim, Aroon D Hingorani, Graham Watt, Tom M Palmer, Nicholas J Timpson, EPIC Study Group, George Davey Smith
发表日期
2012/5/16
来源
Journal of the National Cancer Institute
卷号
104
期号
10
页码范围
740-748
出版商
Oxford University Press
简介
Background
Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.
Methods
We investigated the association of rs1051730 and rs16969968 genotype (referred to as rs1051730–rs16969968, because these are in perfect linkage disequilibrium and interchangeable) with both self-reported daily cigarette consumption and biochemically measured plasma or serum cotinine levels among cigarette smokers. Summary estimates and descriptive statistical data for 12 364 subjects were obtained from six independent studies …
学术搜索中的文章
MR Munafò, MN Timofeeva, RW Morris… - Journal of the National Cancer Institute, 2012