作者
Florian Reizine, Mathieu Lesouhaitier, Murielle Gregoire, Kieran Pinceaux, Arnaud Gacouin, Adel Maamar, Benoit Painvin, Christophe Camus, Yves Le Tulzo, Pierre Tattevin, Matthieu Revest, Audrey Le Bot, Alice Ballerie, Berengère Cador-Rousseau, Mathieu Lederlin, Thomas Lebouvier, Yoann Launey, Maelle Latour, Clotilde Verdy, Delphine Rossille, Simon Le Gallou, Joelle Dulong, Caroline Moreau, Claude Bendavid, Mikael Roussel, Michel Cogne, Karin Tarte, Jean-Marc Tadié
发表日期
2021
期刊
Journal of clinical immunology
页码范围
1-11
出版商
Springer US
简介
Purpose
The SARS-CoV-2 infection can lead to a severe acute respiratory distress syndrome (ARDS) with prolonged mechanical ventilation and high mortality rate. Interestingly, COVID-19-associated ARDS share biological and clinical features with sepsis-associated immunosuppression since lymphopenia and acquired infections associated with late mortality are frequently encountered. Mechanisms responsible for COVID-19-associated lymphopenia need to be explored since they could be responsible for delayed virus clearance and increased mortality rate among intensive care unit (ICU) patients.
Methods
A series of 26 clinically annotated COVID-19 patients were analyzed by thorough phenotypic and functional investigations at days 0, 4, and 7 after ICU admission.
Results
We revealed that, in the absence of any …
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F Reizine, M Lesouhaitier, M Gregoire, K Pinceaux… - Journal of clinical immunology, 2021