作者
Erin P Price, Derek S Sarovich, Mark Mayo, Apichai Tuanyok, Kevin P Drees, Mirjam Kaestli, Stephen M Beckstrom-Sternberg, James S Babic-Sternberg, Timothy J Kidd, Scott C Bell, Paul Keim, Talima Pearson, Bart J Currie
发表日期
2013/8/30
期刊
MBio
卷号
4
期号
4
页码范围
10.1128/mbio. 00388-13
出版商
American Society for Microbiology
简介
Burkholderia pseudomallei causes the potentially fatal disease melioidosis. It is generally accepted that B. pseudomallei is a noncommensal bacterium and that any culture-positive clinical specimen denotes disease requiring treatment. Over a 23-year study of melioidosis cases in Darwin, Australia, just one patient from 707 survivors has developed persistent asymptomatic B. pseudomallei carriage. To better understand the mechanisms behind this unique scenario, we performed whole-genome analysis of two strains isolated 139 months apart. During this period, B. pseudomallei underwent several adaptive changes. Of 23 point mutations, 78% were nonsynonymous and 43% were predicted to be deleterious to gene function, demonstrating a strong propensity for positive selection. Notably, a nonsense mutation inactivated the universal stress response sigma factor RpoS, with pleiotropic implications. The genome …
学术搜索中的文章
EP Price, DS Sarovich, M Mayo, A Tuanyok, KP Drees… - MBio, 2013